Prdm9^repro7
Chemically induced Allele Detail

Summary

• Symbol: Prdm9^repro7
• Name: PR domain containing 9; reproductive mutant 7, JAX Reproductive Mutagenesis Program
• MGI ID: MGI:3512904
• Synonyms: G1-419-29
• Gene: Prdm9 Location: Chr17:15763341-15784616 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Prdm9^repro7 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This ENU induced mutant has a G-to-A transition at chromosome 17 position 15,545,085 (GRCm38) which causes a change in amino acid 478 from glutamine to a premature stop codon (p.Q478*). Mutant germ cells produce a truncated protein detected by an antibody that detects the N-terminal domains. (J:222308, J:250814)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm9 Mutation: 46 strains or lines available

Notes

Males and females are infertile: very low testis weight, no epididymal sperm are recovered; in females, no oocytes are recovered. Histological analysis shows arrest of spermatogenesis during mid-pachytene stage of meiotic prophase, some seminiferous tubules are greatly depleted of germ cells.

References

• Original: J:92463 JAX Reproductive Mutagenesis Program, Heritable mouse mutants from The Jackson Laboratory Reproductive Genomics Mutagenesis Program. MGI Direct Data Submission. 2004-7
• All: 4 reference(s)