Mad2l2^repro22
Chemically induced Allele Detail

Summary

• Symbol: Mad2l2^repro22
• Name: MAD2 mitotic arrest deficient-like 2; reproductive mutant 22, JAX Reproductive Mutagenesis Program
• MGI ID: MGI:3512941
• Synonyms: G1-453-4, Rev7^C70R
• Gene: Mad2l2 Location: Chr4:148214841-148230156 bp, + strand Genetic Position: Chr4, 78.67 cM, cytoband E1
• Alliance: Mad2l2^repro22 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C point mutation that results in the amino acid substitution of arginine for cysteine at position 70 (C70R). (J:209515)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mad2l2 Mutation: 15 strains or lines available

Notes

Males and females are infertile: very low testis weight, no epididymal sperm are recovered. In females, no oocytes recovered. Histological analysis shows germ cell depletion; spermatogonia are present but not later spermatogenic stages. Ovaries are tiny.

References

• Original: J:92463 JAX Reproductive Mutagenesis Program, Heritable mouse mutants from The Jackson Laboratory Reproductive Genomics Mutagenesis Program. MGI Direct Data Submission. 2004-7
• All: 5 reference(s)