Fmgty4^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Fmgty4^C57BL/6J
• Name: femur geometry 4; C57BL/6J
• MGI ID: MGI:3512982
• QTL: Fmgty4 Location: unknown Genetic Position: Chr5, cM position of peak correlated region/allele: 63.84 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased maximum outer fiber length (MaxOFL) compared to BALB/cJ. (J:94352)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94352

487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Nine geometric traits were evaluated for each femur.

Linkage to maximum outer fiber length (MaxOFL) mapped to 68 cM on mouse Chromosome 5 near D5Mit95. This locus is designated Fmgty4. C57BL/6J-derived alleles confer increased MaxOFL compared to BALB/cJ-derived alleles.

References

• Original: J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
• All: 1 reference(s)