Fmgty5^BALB/cJ
QTL Variant Detail

Summary

• QTL variant: Fmgty5^BALB/cJ
• Name: femur geometry 5; BALB/cJ
• MGI ID: MGI:3512989
• QTL: Fmgty5 Location: unknown Genetic Position: Chr6, cM position of peak correlated region/allele: 57.07 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/cJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased average outer fiber length (AveOFL) and medial/lateral axis bending moment of inertia (Iml) compared to C57BL/6J. (J:94352)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94352

487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cMwere used in the genome scan. Nine geometric traits were evaluated for each femur.

Linkage to average outer fiber length (AveOFL) and medial/lateral axis bending moment of inertia (Iml) mapped to 58.6 cM near D6Mit216. This locus is designated Fmgty5. BALB/cJ-derived alleles confer increased AveOFL and Iml compared to C57BL/6J-derived alleles.

References

• Original: J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
• All: 1 reference(s)