Fmgty9^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Fmgty9^C57BL/6J
• Name: femur geometry 9; C57BL/6J
• MGI ID: MGI:3512998
• QTL: Fmgty9 Location: unknown Genetic Position: Chr11, cM position of peak correlated region/allele: 16.31 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased minimum outer fiber length (MinOFL) and average outer fiber length (AveOFL), shape factor (SF), and medial/lateral axis bending moment of inertia (Iml) compared to BALB/cJ. (J:94352)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94352

487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Nine geometric traits were evaluated for each femur.

Linkage to cortical thickness, minimum outer fiber length (MinOFL), average outer fiber length (AveOFL), shape factor (SF), and medial/lateral axis bending moment of inertia (Iml) map to 16 cM on mouse Chromosome 11 near D11Mit83. This locus is designated Fmgty9. C57BL/6J-derived alleles confer increased SF, Iml, AveOFL, and MinOFL compared to BALB/cJ-derived alleles. C3H/HeJ-derived alleles confer increased cortical thickness compared to DBA/2J-derived alleles.

References

• Original: J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
• All: 1 reference(s)