Fmgty11^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Fmgty11^C3H/HeJ
• Name: femur geometry 11; C3H/HeJ
• MGI ID: MGI:3513017
• QTL: Fmgty11 Location: unknown Genetic Position: Chr14, cM position of peak correlated region/allele: 56.16 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased shape factor compared to DBA/2J. (J:94352)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94352

487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Nine geometric traits were evaluated for each femur.

Linkage to standard deviation of outer fiber length (StdOFL) and shape factor (SF) mapped to 63 cM on mouse Chromosome 14 near D14Mit170. This locus is designated Fmgty11. DBA/2J-derived alleles confer increased StdOFL compared to C3H/HeJ-derived alleles, and C3H/HeJ-derived alleles confer increased SF compared to DBA/2J-derived alleles.

References

• Original: J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
• All: 1 reference(s)