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Fmgty13C57BL/6J
QTL Variant Detail
Summary
QTL variant: Fmgty13C57BL/6J
Name: femur geometry 13; C57BL/6J
MGI ID: MGI:3513022
QTL: Fmgty13  Location: unknown  Genetic Position: Chr15, cM position of peak correlated region/allele: 45.02 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94352

487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Nine geometric traits were evaluated for each femur.

Linkage to cross sectional area (CSA), maximum outer fiber length (MaxOFL), average outer fiber length (AveOFL), medial/lateral axis bending moment of inertia (Iml), andanterior/posterior bending moment of inertia (Iap) map to 21 cM on mouse Chromosome 15 near D15Mit100. This locus is designated Fmgty12. C3H/HeJ-derived alleles confer increased CSA, MaxOFL, AveOFL, Iml, and Iap compared to DBA/2J-derived alleles.

Linkage to minimum outer fiber length (MinOFL), average outer fiber length (AveOFL), and medial/lateral axis bending moment of inertia (Iml) map to 54.5 cM on mouse Chromosome 15 near D15Mit171. This locus is designated Fmgty13. BALB/cJ-derived alleles conferincreased MinOFL, AveOFL, and Iml compared to C57BL/6J-derived alleles.

References
Original:  J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory