Crhbp^tm1Afs
Targeted Allele Detail

Summary

• Symbol: Crhbp^tm1Afs
• Name: corticotropin releasing hormone binding protein; targeted mutation 1, Audrey F Seasholtz
• MGI ID: MGI:3513042
• Gene: Crhbp Location: Chr13:95567884-95581339 bp, - strand Genetic Position: Chr13, 49.5 cM
• Alliance: Crhbp^tm1Afs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57963
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The translated portion of exon 1 and all of exons 2-5 were replaced with a PGK-neomycin resistance cassette. In situ hybridization confirmed the absence of transcripts in the cerebral cortex. (J:57963)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crhbp Mutation: 24 strains or lines available

References

• Original: J:57963 Karolyi IJ, et al., Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11595-600
• All: 2 reference(s)