Prl4a1^tm1Soar
Targeted Allele Detail

Summary

• Symbol: Prl4a1^tm1Soar
• Name: prolactin family 4, subfamily a, member 1; targeted mutation 1, Michael J Soares
• MGI ID: MGI:3513079
• Gene: Prl4a1 Location: Chr13:28200195-28207531 bp, + strand Genetic Position: Chr13, 12.66 cM
• Alliance: Prl4a1^tm1Soar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94464
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin cassette replaced exons 2-5. Exon 1 remains but codes only for the first 10 amino acids of the signal peptide. Absence of transcription and translation was confirmed by Northern and Western blot analyses, QRT-PCR and in situ hybridization. (J:94464)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prl4a1 Mutation: 11 strains or lines available

References

• Original: J:94464 Ain R, et al., A prolactin family paralog regulates reproductive adaptations to a physiological stressor. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16543-8
• All: 1 reference(s)