Tubb1^tm1Shiv
Targeted Allele Detail

Summary

• Symbol: Tubb1^tm1Shiv
• Name: tubulin, beta 1 class VI; targeted mutation 1, Ramesh A Shivdasani
• MGI ID: MGI:3513083
• Synonyms: Beta1-tubulin^-
• Gene: Tubb1 Location: Chr2:174292488-174299675 bp, + strand Genetic Position: Chr2, 97.95 cM, cytoband H
• Alliance: Tubb1^tm1Shiv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94498
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3, which encodes amino acids 56-451, was replaced with a PGK-neo cassette. Immunoblot of mutant megakaryocytes confirmed a lack of protein. (J:94498)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tubb1 Mutation: 27 strains or lines available

References

• Original: J:94498 Schwer HD, et al., A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001 Apr 17;11(8):579-86
• All: 5 reference(s)