Egfr^tm1Dwt
Targeted Allele Detail

Summary

• Symbol: Egfr^tm1Dwt
• Name: epidermal growth factor receptor; targeted mutation 1, David W Threadgill
• MGI ID: MGI:3513096
• Synonyms: Egfr^fl
• Gene: Egfr Location: Chr11:16702203-16868158 bp, + strand Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
• Alliance: Egfr^tm1Dwt page

Placenta abnormalities in Egfr^tm1Dwt/Egfr^tm1Dwt Tg(EIIa-cre)C5379Lmgd/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145161
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A floxed neo cassette was inserted upstream of exon 3 and an additional loxP site was inserted downstream of exon 3. Transient cre expression was used to remove the neo cassette leaving exon 3 floxed. (J:145161)

Generation of the Egfr^tm1Dwt allele

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egfr Mutation: 87 strains or lines available

References

• Original: J:145161 Lee TC, et al., Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis. 2009 Feb;47(2):85-92
• All: 67 reference(s)