Tgfb1^tm1Jmu
Targeted Allele Detail

Summary

• Symbol: Tgfb1^tm1Jmu
• Name: transforming growth factor, beta 1; targeted mutation 1, John Munger
• MGI ID: MGI:3513111
• Synonyms: Tgfb1^RGE
• Gene: Tgfb1 Location: Chr7:25386427-25404502 bp, + strand Genetic Position: Chr7, 13.98 cM
• Alliance: Tgfb1^tm1Jmu page

Tgfb1^tm1Jmu/Tgfb1^tm1Jmu mice develop fatal multiorgan inflammation

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120085
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted in the intron between exons 5 and 6. In exon 5, a mutation was introduced that changes a D codon to an E codon (D246E); this mutates the RGD integrin binding site in the propeptide to RGE. (J:120085)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfb1 Mutation: 35 strains or lines available

References

• Original: J:120085 Yang Z, et al., Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. J Cell Biol. 2007 Mar 12;176(6):787-93
• All: 3 reference(s)