Igh-J^{tm1(3H9-VDJ)Mwg}
Targeted Allele Detail

Summary

• Symbol: Igh-J^{tm1(3H9-VDJ)Mwg}
• Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Martin Weigert
• MGI ID: MGI:3513167
• Synonyms: 3H9, 3H9.KI, 3H9R, 3H9 sd-tg, IgH^3H9, VH3H9R, VH3H9 Tg
• Gene: Igh-J Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94501
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intergenic deletion
• Mutation details: The endogenous DQ52 and all four heavy chain J elements were replaced by a rearranged heavy chain V 3H9 gene encoding an H chain of anti-dsDNA antibody and a neomycin resistance gene. (J:94501)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Igh-J Mutation: 13 strains or lines available

References

• Original: J:94501 Chen C, et al., Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity. 1995 Dec;3(6):747-55
• All: 30 reference(s)