Igk-J^tm1Mwg
Targeted Allele Detail

Summary

• Symbol: Igk-J^tm1Mwg
• Name: immunoglobulin kappa chain, joining region; targeted mutation 1, Martin Weigert
• MGI ID: MGI:3513200
• Synonyms: Igkappa^Vkappa4, Vkappa4R
• Gene: Igk-J Location: unknown Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76116
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A targeting vector was designed to replace J1-J3 with a rearranged Vkappa4Jkappa4 gene. An upstream neo was included. (J:76116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igk-J Mutation: 11 strains or lines available

Notes

E14.1 ES cells were also electroporated.

References

• Original: J:76116 Prak EL, et al., Light chain replacement: a new model for antibody gene rearrangement. J Exp Med. 1995 Aug 1;182(2):541-8
• All: 8 reference(s)