Igk-J^tm2Mwg
Targeted Allele Detail

Summary

• Symbol: Igk-J^tm2Mwg
• Name: immunoglobulin kappa chain, joining region; targeted mutation 2, Martin Weigert
• MGI ID: MGI:3513201
• Synonyms: Vkappa8Jkappa5, Vkappa8R
• Gene: Igk-J Location: unknown Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76116
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace J1-J4 with a rearranged Vkappa8Jkappa5 gene. An upstream neo was included. (J:76116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Igk-J Mutation: 11 strains or lines available

Notes

BL/6-III ES cells were also used.

References

• Original: J:76116 Prak EL, et al., Light chain replacement: a new model for antibody gene rearrangement. J Exp Med. 1995 Aug 1;182(2):541-8
• All: 16 reference(s)