Grin2c^{tm1(Grin2b)Ulme}
Targeted Allele Detail

Summary

• Symbol: Grin2c^{tm1(Grin2b)Ulme}
• Name: glutamate receptor, ionotropic, NMDA2C (epsilon 3); targeted mutation 1, Ulrich, LM Eisel
• MGI ID: MGI:3513208
• Synonyms: NR2C-2B
• Gene: Grin2c Location: Chr11:115139995-115158069 bp, - strand Genetic Position: Chr11, 80.8 cM
• Alliance: Grin2c^{tm1(Grin2b)Ulme} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94369
• Parent Cell Line: REK4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cDNA encoding Grin2b and a neomycin resistance gene was inserted directly 3' of the ATG and thereby replaced the endogenous signal sequence. In situ hybridization of brain sections indicated that Grin2b transcript was present in mutant mice. Western blot also indicated the lack of Grin2c protein, while Grin2b protein was present. (J:94369)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2c Mutation: 56 strains or lines available

References

• Original: J:94369 Schlett K, et al., Long-term NR2B expression in the cerebellum alters granule cell development and leads to NR2A down-regulation and motor deficits. Mol Cell Neurosci. 2004 Nov;27(3):215-26
• All: 5 reference(s)