Mtmr2^tm1Abol
Targeted Allele Detail

Summary

• Symbol: Mtmr2^tm1Abol
• Name: myotubularin related protein 2; targeted mutation 1, Alessandra Bolino
• MGI ID: MGI:3513251
• Synonyms: Mtmr2^Fl
• Gene: Mtmr2 Location: Chr9:13659706-13717777 bp, + strand Genetic Position: Chr9, 3.44 cM, cytoband A1
• Alliance: Mtmr2^tm1Abol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94373
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites flanking exon 4 and a FRT-flanked neo cassette into intron 4. (J:94373)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtmr2 Mutation: 38 strains or lines available

References

• Original: J:94373 Bolino A, et al., Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis. J Cell Biol. 2004 Nov 22;167(4):711-21
• All: 2 reference(s)