Apc^tm1Cip
Targeted Allele Detail

Summary

• Symbol: Apc^tm1Cip
• Name: APC, WNT signaling pathway regulator; targeted mutation 1, Christine Perret
• MGI ID: MGI:3513416
• Synonyms: Apc^delta14
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm1Cip page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94108
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 13 and a loxP flanked PGK-Hprt cassette into intron 14. Crossing with transgenic mice expressing Cre in the germline excised exon 14 and the Hprt cassette. RT-PCR indicated the lack of transcript in colon samples from mutants. (J:94108)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm1Cip

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:94108 Colnot S, et al., Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. Lab Invest. 2004 Dec;84(12):1619-30
• All: 26 reference(s)