Lalba^{tm1.1(LALBA)Asty}
Targeted Allele Detail

Summary

• Symbol: Lalba^{tm1.1(LALBA)Asty}
• Name: lactalbumin, alpha; targeted mutation 1.1, Alexander Stacey
• MGI ID: MGI:3513837
• Synonyms: Alpha-lac^h, HMAL
• Gene: Lalba Location: Chr15:98378281-98380602 bp, - strand Genetic Position: Chr15, 54.48 cM
• Alliance: Lalba^{tm1.1(LALBA)Asty} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16483
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: ES cells containing the Lalba^tm1Asty mutation were further targeted with a vector designed to replace the HPRT minigene with human LALBA cDNA. (J:16483)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lalba Mutation: 8 strains or lines available

References

• Original: J:16483 Stacey A, et al., Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice. Mol Cell Biol. 1994 Feb;14(2):1009-16
• All: 2 reference(s)