Lalba^tm1Jvt
Targeted Allele Detail

Summary

• Symbol: Lalba^tm1Jvt
• Name: lactalbumin, alpha; targeted mutation 1, J L Vilotte
• MGI ID: MGI:3513842
• Synonyms: Alphalac^-
• Gene: Lalba Location: Chr15:98378281-98380602 bp, - strand Genetic Position: Chr15, 54.48 cM
• Alliance: Lalba^tm1Jvt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19377
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An HSV-neo replaced the region spanning 0.56 kb of the 5' flanking sequence to the transcription region upstream from intron 2. Northern blot revealed an absence of mRNA in mammary gland of mutant mice and Western blot confirmed the absence of protein. (J:19377)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lalba Mutation: 8 strains or lines available

References

• Original: J:19377 Stinnakre MG, et al., Creation and phenotypic analysis of alpha-lactalbumin-deficient mice. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6544-8
• All: 1 reference(s)