Htr5a^tm1Rhn
Targeted Allele Detail

Summary

• Symbol: Htr5a^tm1Rhn
• Name: 5-hydroxytryptamine (serotonin) receptor 5A; targeted mutation 1, Rene Hen
• MGI ID: MGI:3513844
• Synonyms: 5A-KO
• Gene: Htr5a Location: Chr5:28046836-28059403 bp, + strand Genetic Position: Chr5, 13.24 cM, cytoband A3-B
• Alliance: Htr5a^tm1Rhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54098
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace 23% of the coding sequence, including the first and second transmembrane domains, with a neomycin resistance gene. A lack of transcript as shown by Northern blot of brain tissues confirmed successful targeting. (J:54098)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr5a Mutation: 19 strains or lines available

References

• Original: J:54098 Grailhe R, et al., Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. Neuron. 1999 Mar;22(3):581-91
• All: 2 reference(s)