Prss16^tm1Cbo
Targeted Allele Detail

Summary

• Symbol: Prss16^tm1Cbo
• Name: serine protease 16 (thymus); targeted mutation 1, Christopher L Bowlus
• MGI ID: MGI:3514011
• Synonyms: Prss16^-
• Gene: Prss16 Location: Chr13:22186346-22193911 bp, - strand Genetic Position: Chr13, 8.12 cM, cytoband A3-A5
• Alliance: Prss16^tm1Cbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94751
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A 6 kb region extending from exon 5 into exon 10, including the active serine site in exon 5, was replaced with a neomycin resistance cassette. ES cell clone 1A4 generated the mice reported. RT-PCR and Northern blot analysis confirmed the absence of transcript. (J:94751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prss16 Mutation: 41 strains or lines available

References

• Original: J:94751 Cheunsuk S, et al., Prss16 is not required for T-cell development. Mol Cell Biol. 2005 Jan;25(2):789-96
• All: 1 reference(s)