Rgs14^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Rgs14^tm1Pngr
• Name: regulator of G-protein signaling 14; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:3514019
• Gene: Rgs14 Location: Chr13:55517545-55532500 bp, + strand Genetic Position: Chr13, 29.8 cM
• Alliance: Rgs14^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94516
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 9, including the those encoding the RGS-box, were replaced with a PGK-neo construct via homologous recombination. Immunofluorescence confirmed the absence of protein in 1-cell stage zygotes. (J:94516)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs14 Mutation: 32 strains or lines available

References

• Original: J:94516 Martin-McCaffrey L, et al., RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell. 2004 Nov;7(5):763-9
• All: 1 reference(s)