Pank2^tm1Jgt
Targeted Allele Detail

Summary

• Symbol: Pank2^tm1Jgt
• Name: pantothenate kinase 2; targeted mutation 1, Jane Gitschier
• MGI ID: MGI:3514020
• Synonyms: Pank2^-
• Gene: Pank2 Location: Chr2:131104415-131141108 bp, + strand Genetic Position: Chr2, 63.31 cM
• Alliance: Pank2^tm1Jgt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94753
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.3 kb fragment containing half of exon 2 and part of intron 2 was replaced with a lacZ and neomycin resistance cassette driven by the polII promoter. RT-PCR and Western blot analysis confirmed the absence of transcription and translation products. (J:94753)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pank2 Mutation: 35 strains or lines available

References

• Original: J:94753 Kuo YM, et al., Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia. Hum Mol Genet. 2005 Jan 1;14(1):49-57
• All: 4 reference(s)