Hand1^tm2Eno
Targeted Allele Detail

Summary

• Symbol: Hand1^tm2Eno
• Name: heart and neural crest derivatives expressed 1; targeted mutation 2, Eric N Olson
• MGI ID: MGI:3514024
• Synonyms: Hand1^fx
• Gene: Hand1 Location: Chr11:57719539-57722973 bp, - strand Genetic Position: Chr11, 35.27 cM
• Alliance: Hand1^tm2Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94514
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The first exon was flanked with loxP sites via homologous recombination. An upstream FRT-flanked neo resistance cassette was removed by crossing with Tg(ACTFLPe)9205Dym transgenic mice. (J:94514)

Expression

In Mice Carrying this Mutation:	54 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand1 Mutation: 15 strains or lines available

References

• Original: J:94514 McFadden DG, et al., The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development. 2005 Jan;132(1):189-201
• All: 9 reference(s)