Tg(Nkx2-5-cre)9Eno
Transgene Detail

Summary

• Symbol: Tg(Nkx2-5-cre)9Eno
• Name: transgene insertion 9, Eric N Olson
• MGI ID: MGI:3514028
• Synonyms: Nk9, Nkx2.5-Cre, Nkx2.5::Cre, Nkx2.5Cre
• Transgene: Tg(Nkx2-5-cre)9Eno Location: unknown
• Alliance: Tg(Nkx2-5-cre)9Eno page

Ultrastructural nuclear abnormalities in Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1ChenSyne2^tm1.1Chen Tg(Nkx2-5-cre)9Eno/? cardiomyocytes

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Nkx2-5-cre)9Eno expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nkx2-5 (MGI:97350)

• Mutation details: A 2.5 kb fragment containing the mouse Nkx2.5 basal promoter and cardiac enhancer was placed in front of an NLS-cre cassette. Expression of cre is seen in developing heart, pharynx, and some liver cells. Three lines were created and line 9, which had the highest levels of cre recombination in the heart, was selected for use. (J:94514)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx2-5 (mouse) Summary of all recombinase alleles driven by Nkx2-5. Comparative matrix view of recombinase activities Alliance mouse Nkx2-5 gene page

Expression

In Mice Carrying this Mutation:

46 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:94514 McFadden DG, et al., The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development. 2005 Jan;132(1):189-201
• All: 23 reference(s)