Abcg8^tm1Elk
Targeted Allele Detail

Summary

• Symbol: Abcg8^tm1Elk
• Name: ATP binding cassette subfamily G member 8; targeted mutation 1, Eric L Klett
• MGI ID: MGI:3514037
• Synonyms: Abcg8^-, Abcg8/sterolin2
• Gene: Abcg8 Location: Chr17:84983730-85007761 bp, + strand Genetic Position: Chr17, 55.02 cM
• Alliance: Abcg8^tm1Elk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94759
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 through part of exon 4 was replaced by a neomycin resistance cassette resulting in disruption of the ABC Walker A motif. No transcription was detected by Northern blot analysis. (J:94759)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abcg8 Mutation: 30 strains or lines available

References

• Original: J:94759 Klett EL, et al., A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med. 2004 Mar 24;2(1):5
• All: 14 reference(s)