Vav3^tm1Xrb
Targeted Allele Detail

Summary

• Symbol: Vav3^tm1Xrb
• Name: vav 3 oncogene; targeted mutation 1, Xose R Bustelo
• MGI ID: MGI:3514154
• Synonyms: Vav3^-
• Gene: Vav3 Location: Chr3:109247969-109593014 bp, + strand Genetic Position: Chr3, 48.13 cM, cytoband G1
• Alliance: Vav3^tm1Xrb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111973
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter region and half of Exon 1 were eliminated. QRT-PCR, in situ hybridization, immunohistochemistry, and Western blot analysis confirmed the absence of transcription and translation. (J:111973)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav3 Mutation: 56 strains or lines available

Notes

ES Cell line = 0101, Lot 3/2/01

References

• Original: J:111973 Sauzeau V, et al., Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction. Nat Med. 2006 Jul;12(7):841-5
• All: 20 reference(s)