Park7^tm1Tmd
Targeted Allele Detail

Summary

• Symbol: Park7^tm1Tmd
• Name: Parkinson disease (autosomal recessive, early onset) 7; targeted mutation 1, Ted Dawson
• MGI ID: MGI:3514165
• Synonyms: DJ-1^-
• Gene: Park7 Location: Chr4:150981590-150994378 bp, - strand Genetic Position: Chr4, 81.52 cM, cytoband E1
• Alliance: Park7^tm1Tmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125021
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced part of exon 2 and all of exon 3. Absence of protein product was confirmed by immunohistochemistry and western blot analysis. (J:125021)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Park7 Mutation: 56 strains or lines available

References

• Original: J:125021 Andres-Mateos E, et al., DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14807-12
• All: 9 reference(s)