Lrrk2^tm1Tmd
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm1Tmd
• Name: leucine-rich repeat kinase 2; targeted mutation 1, Ted Dawson
• MGI ID: MGI:3514169
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm1Tmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143967
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a floxed neomycin resistance cassette partially deletes exon 39 and completely deletes exon 40. No protein expression was detected in homozygous brain lysates as determined by immunoblot analysis. (J:143967)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 159 strains or lines available

References

• Original: J:143967 Biskup S, et al., Dynamic and redundant regulation of LRRK2 and LRRK1 expression. BMC Neurosci. 2007;8:102
• All: 5 reference(s)