Hoxb6^tm1Cka
Targeted Allele Detail

Summary

• Symbol: Hoxb6^tm1Cka
• Name: homeobox B6; targeted mutation 1, Claudia Kappen
• MGI ID: MGI:3514269
• Synonyms: Hoxb-6^hd
• Gene: Hoxb6 Location: Chr11:96183647-96192395 bp, + strand Genetic Position: Chr11, 59.82 cM
• Alliance: Hoxb6^tm1Cka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133561
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The part of exon 2 that encodes the homeobox and the exon 2 splice acceptor site was replaced with a neo cassette. (J:133561)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hoxb6 Mutation: 14 strains or lines available

References

• Original: J:133561 Kappen C, Disruption of the homeobox gene Hoxb-6 in mice results in increased numbers of early erythrocyte progenitors. Am J Hematol. 2000 Oct;65(2):111-8
• All: 2 reference(s)