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Tg(KRT14-HPV16E7)2350Plam
Transgene Detail
Summary
Symbol: Tg(KRT14-HPV16E7)2350Plam
Name: transgene insertion 2350, Paul F Lambert
MGI ID: MGI:3514323
Synonyms: 2350, K14HPV16E7
Transgene: Tg(KRT14-HPV16E7)2350Plam  Location: unknown  
Alliance: Tg(KRT14-HPV16E7)2350Plam page
Transgene
origin
Strain of Origin:  FVB/NTac
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene contains a HPV16 fragment (NT79-883) encompassing both the E6 and E7 genes along with promoter, 3' UTR, and polyA sequences from human KRT14. Only E7 was expressed due to the presence of a translation termination linker (ttl) in the N terminal region of the E6 gene. Transgene expression was targeted to epithelial tissues. Mice derived from this founder had 20-21 copies of the transgene. (J:86018)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(KRT14-HPV16E7)2350Plam
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:86018 Herber R, et al., Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene. J Virol. 1996 Mar;70(3):1873-81
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory