Tg(KRT14-HPV16E7)2350Plam
Transgene Detail

Summary

• Symbol: Tg(KRT14-HPV16E7)2350Plam
• Name: transgene insertion 2350, Paul F Lambert
• MGI ID: MGI:3514323
• Synonyms: 2350, K14HPV16E7
• Transgene: Tg(KRT14-HPV16E7)2350Plam Location: unknown
• Alliance: Tg(KRT14-HPV16E7)2350Plam page

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains a HPV16 fragment (NT79-883) encompassing both the E6 and E7 genes along with promoter, 3' UTR, and polyA sequences from human KRT14. Only E7 was expressed due to the presence of a translation termination linker (ttl) in the N terminal region of the E6 gene. Transgene expression was targeted to epithelial tissues. Mice derived from this founder had 20-21 copies of the transgene. (J:86018)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT14-HPV16E7)2350Plam

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:86018 Herber R, et al., Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene. J Virol. 1996 Mar;70(3):1873-81
• All: 1 reference(s)