Il10^tm1Roer
Targeted Allele Detail

Summary

• Symbol: Il10^tm1Roer
• Name: interleukin 10; targeted mutation 1, Axel Roers
• MGI ID: MGI:3521568
• Synonyms: IL-10^FL
• Gene: Il10 Location: Chr1:130947582-130952711 bp, + strand Genetic Position: Chr1, 56.89 cM
• Alliance: Il10^tm1Roer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94537
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to place a loxP site upstream of exon 1 and a loxP-flanked neomycin cassette downstream of exon 1. Cre-mediated recombination removed the floxed neo cassette. (J:94537)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il10 Mutation: 45 strains or lines available

References

• Original: J:94537 Roers A, et al., T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med. 2004 Nov 15;200(10):1289-97
• All: 54 reference(s)