Ntrk3^tm1(cre)Lfr
Targeted Allele Detail

Summary

• Symbol: Ntrk3^tm1(cre)Lfr
• Name: neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1, Louis F Reichardt
• MGI ID: MGI:3521571
• Synonyms: Ntrk3^tm1(cre)Rice, Ntrk3^tm(cre)1Lfr
• Gene: Ntrk3 Location: Chr7:77825711-78228865 bp, - strand Genetic Position: Chr7, 44.01 cM
• Alliance: Ntrk3^tm1(cre)Lfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Ntrk3^tm1(cre)Lfr expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ntrk3 (MGI:97385)

• Mutation details: An IRES-Cre-SV40pA and FRT-flanked neo cassette was inserted 52 bp downstream of the stop codon into exon 18. Crossing with mice expressing Flp recombinase removed the neo. Northern blot showed expression of a shorter transcript than wild-type, indicating that the wild-type transcript contains a long 3' UTR, which was truncated by the insertion of the SV40 after the Cre. (J:94575)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ntrk3 (mouse) Summary of all recombinase alleles driven by Ntrk3. Alliance mouse Ntrk3 gene page

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntrk3 Mutation: 67 strains or lines available

References

• Original: J:94575 Funfschilling U, et al., TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells. J Comp Neurol. 2004 Dec 20;480(4):392-414
• All: 9 reference(s)