Hap1^tm1Id
Targeted Allele Detail

Summary

• Symbol: Hap1^tm1Id
• Name: huntingtin-associated protein 1; targeted mutation 1, Ioannis Dragatsis
• MGI ID: MGI:3521576
• Gene: Hap1 Location: Chr11:100238153-100246954 bp, - strand Genetic Position: Chr11, 63.47 cM, cytoband D
• Alliance: Hap1^tm1Id page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94581
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A targeting vector was designed to replace 5 kb of sequence containing the promoter, exon 1 and a portion of intron 1 with a neo cassette placed in opposite orientation of transcription. Northern blot indicated the absence of transcript in mutant neonatal mouse brains. (J:94581)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hap1 Mutation: 37 strains or lines available

References

• Original: J:94581 Dragatsis I, et al., Huntingtin-associated protein 1 (Hap1) mutant mice bypassing the early postnatal lethality are neuroanatomically normal and fertile but display growth retardation. Hum Mol Genet. 2004 Dec 15;13(24):3115-25
• All: 1 reference(s)