Ins2^tm1Delt
Targeted Allele Detail

Summary

• Symbol: Ins2^tm1Delt
• Name: insulin II; targeted mutation 1, Louise Deltour
• MGI ID: MGI:3521584
• Synonyms: Ins2^dta
• Gene: Ins2 Location: Chr7:142232393-142233463 bp, - strand Genetic Position: Chr7, 88.0 cM
• Alliance: Ins2^tm1Delt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94589
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace sequence from the 3' end of exon 1 to the 5' end of exon 3 with a diphtheria toxin-A (dta) chain gene and a neo. The dta was linked to the noncoding first 20 bp of exon 1. (J:94589)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ins2 Mutation: 93 strains or lines available

References

• Original: J:94589 Lamotte L, et al., Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain. Transgenic Res. 2004 Oct;13(5):463-73
• All: 1 reference(s)