Ccr9^tm1Ccb
Targeted Allele Detail

Summary

• Symbol: Ccr9^tm1Ccb
• Name: C-C motif chemokine receptor 9; targeted mutation 1, Conrad C Bleul
• MGI ID: MGI:3521585
• Synonyms: CCR9^EGFP, EGFP^CCR9
• Gene: Ccr9 Location: Chr9:123596276-123612522 bp, + strand Genetic Position: Chr9, 74.33 cM, cytoband F
• Alliance: Ccr9^tm1Ccb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94596
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon containing most of the coding sequence was replaced in-frame by an EGFP and Hyg cassette. RT-PCR indicated a lack of Ccr9 transcript in mutant thymocytes, while FACS showed EGFP expression. (J:94596)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccr9 Mutation: 31 strains or lines available

References

• Original: J:94596 Benz C, et al., Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development. Eur J Immunol. 2004 Dec;34(12):3652-63
• All: 5 reference(s)