Cysltr2^tm1Ykn
Targeted Allele Detail

Summary

• Symbol: Cysltr2^tm1Ykn
• Name: cysteinyl leukotriene receptor 2; targeted mutation 1, Yoshihide Kanaoka
• MGI ID: MGI:3521667
• Synonyms: CysLT2^-, CYSLT2R KO, Cystr2^-
• Gene: Cysltr2 Location: Chr14:73263043-73286554 bp, - strand Genetic Position: Chr14, 38.54 cM
• Alliance: Cysltr2^tm1Ykn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94488
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neo into exon 6 interrupted 85% of the coding sequence. Northern blot showed a lack of transcript in mutant lung, spleen and small intestine. (J:94488)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cysltr2 Mutation: 33 strains or lines available

References

• Original: J:94488 Beller TC, et al., Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J Biol Chem. 2004 Oct 29;279(44):46129-34
• All: 20 reference(s)