Kcnn4^tm1Jemn
Targeted Allele Detail

Summary

• Symbol: Kcnn4^tm1Jemn
• Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; targeted mutation 1, James E Melvin
• MGI ID: MGI:3521668
• Synonyms: IK1^-, KCa3.1, KCa3.1-, Kcnn4^-
• Gene: Kcnn4 Location: Chr7:24069750-24084635 bp, + strand Genetic Position: Chr7, 10.37 cM
• Alliance: Kcnn4^tm1Jemn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94478
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was deleted upon incorporation of a PGK-neo cassette into the locus. Northern blot showed a lack of transcript in mutant CD4+ T lymphocytes. (J:94478)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kcnn4 Mutation: 22 strains or lines available

References

• Original: J:94478 Begenisich T, et al., Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem. 2004 Nov 12;279(46):47681-7
• All: 28 reference(s)