Ahr^tm3Bra
Targeted Allele Detail

Summary

• Symbol: Ahr^tm3Bra
• Name: aryl-hydrocarbon receptor; targeted mutation 3, Christopher A Bradfield
• MGI ID: MGI:3521676
• Synonyms: Ahr^fxneo
• Gene: Ahr Location: Chr12:35547978-35584988 bp, - strand Genetic Position: Chr12, 15.78 cM
• Alliance: Ahr^tm3Bra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94465
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A hypomorphic allele was generated by inserting a neo cassette flanked by loxP sites 5' of exon 2, which encodes the basic-HLH domain essential for dimerization and DNA binding. A third loxP site was inserted 3' of exon 2. The ES cell line and library used contained the Ahr^d allele. Western blot analysis confirmed decreased expression in liver, kidney, heart, lung and spleen from homozygous mice. (J:94465)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ahr Mutation: 112 strains or lines available

References

• Original: J:94465 Walisser JA, et al., Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16677-82
• All: 2 reference(s)