Hoxa13^tm1Jwi
Targeted Allele Detail

Summary

• Symbol: Hoxa13^tm1Jwi
• Name: homeobox A13; targeted mutation 1, Jeffrey W Innis
• MGI ID: MGI:3521726
• Synonyms: Hoxa13^Ala28
• Gene: Hoxa13 Location: Chr6:52235833-52237865 bp, - strand Genetic Position: Chr6, 25.41 cM
• Alliance: Hoxa13^tm1Jwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94412
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Homologous recombination was used to insert 10 additional alanine residues into repeat III, bringing the largest polyalanine sequence up to 28 residues. (J:94412)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hoxa13 Mutation: 29 strains or lines available

References

• Original: J:94412 Innis JW, et al., Polyalanine expansion in HOXA13: three new affected families and the molecular consequences in a mouse model. Hum Mol Genet. 2004 Nov 15;13(22):2841-51
• All: 1 reference(s)