Prop1^tm1Sac
Targeted Allele Detail

Summary

• Symbol: Prop1^tm1Sac
• Name: paired like homeodomain factor 1; targeted mutation 1, Sally A Camper
• MGI ID: MGI:3521736
• Synonyms: Prop1^-
• Gene: Prop1 Location: Chr11:50841633-50844584 bp, - strand Genetic Position: Chr11, 30.95 cM
• Alliance: Prop1^tm1Sac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94409
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Sequence spanning from the ATG in exon 1 to part of exon 2 was replaced with a LacZ-neo cassette. (J:94409)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prop1 Mutation: 15 strains or lines available

References

• Original: J:94409 Nasonkin IO, et al., Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice. Hum Mol Genet. 2004 Nov 15;13(22):2727-35
• All: 7 reference(s)