Hlbsb1^SPRET/Pt
QTL Variant Detail

Summary

• QTL variant: Hlbsb1^SPRET/Pt
• Name: hepatic lipase activity in BSB 1; SPRET/Pt
• MGI ID: MGI:3521779
• QTL: Hlbsb1 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 73.19 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SPRET/Pt

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased hepatic lipase activity compared to C57BL/6J. (J:94152)

Notes

This allele also interacts epistatically with Hlbsb2. Animals carrying SPRET/Pt alleles at both Hlbsb1 and Hlbsb2 exhibit enhanced hepatic lipase activity.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94152

A population of 5 month old BSB backcross (B=C57BL/6J; S=Spret/Pt) animals (n=203) were examined for linkage to hepatic lipase activity. 148 polymorphic markers covering 90% of the genome at an average resolution of 10 cM were used in the genome scan.

Hlbsb1 (hepatic lipase activity in BSB 1) mapped to 64 cM on mouse Chromosome 7 with a peak LOD score of 4.8 near D7Mit187a. Hlbsb1 accounts for approximately 10.67% of the phenotypic variance. The QTL interval of Hlbsb1 spans approximately 48 cM - 66 cM.SPRET/Pt-derived alleles confer increased hepatic lipase activity at Hlbsb1. Hlbsb1 maps near a previously identified obesity/HDL/hepatic lipase QTL named Mob1 (62 cM).

A second interacting locus was identified on mouse Chromosome 3 at 66.4 cM near D3Mit18 and is named Hlbsb2. SPRET/Pt-derived alleles confer increased hepatic lipase activity at Hlbsb2 in epistatic interactions with Hlbsb1. Animals with SPRET/Pt-derived alleles at both Hlbsb1 and Hlbsb2 exhibit enhanced hepatic lipase activity. The interaction between Hlbsb1 and Hlbsb2 explains approximately 7.03% of the phenotypic variance.

References

• Original: J:94152 Yi N, et al., Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice. J Lipid Res. 2004 Nov;45(11):2063-70
• All: 1 reference(s)