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Hlbsb2C57BL/6J
QTL Variant Detail
Summary
QTL variant: Hlbsb2C57BL/6J
Name: hepatic lipase activity in BSB 2; C57BL/6J
MGI ID: MGI:3521780
QTL: Hlbsb2  Location: unknown  Genetic Position: Chr3, cM position of peak correlated region/allele: 72.36 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94152

A population of 5 month old BSB backcross (B=C57BL/6J; S=Spret/Pt) animals (n=203) were examined for linkage to hepatic lipase activity. 148 polymorphic markers covering 90% of the genome at an average resolution of 10 cM were used in the genome scan.

Hlbsb1 (hepatic lipase activity in BSB 1) mapped to 64 cM on mouse Chromosome 7 with a peak LOD score of 4.8 near D7Mit187. Hlbsb1 accounts for approximately 10.67% of the phenotypic variance. The QTL interval of Hlbsb1 spans approximately 48 cM - 66 cM. SPRET/Pt-derived alleles confer increased hepatic lipase activity at Hlbsb1. Hlbsb1 maps near a previously identified obesity/HDL/hepatic lipase QTL named Mob1 (62 cM).

A second interacting locus was identified on mouse Chromosome 3 at 66.4 cM near D3Mit18 and is named Hlbsb2. SPRET/Pt-derived alleles confer increased hepatic lipase activity at Hlbsb2 in epistatic interactions with Hlbsb1. Animals with SPRET/Pt-derived alleles at both Hlbsb1 and Hlbsb2 exhibit enhanced hepatic lipase activity. The interaction between Hlbsb1 and Hlbsb2 explains approximately 7.03% of the phenotypic variance.

References
Original:  J:94152 Yi N, et al., Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice. J Lipid Res. 2004 Nov;45(11):2063-70
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory