About   Help   FAQ
Hlbsb2C57BL/6J
QTL Variant Detail
Summary
QTL variant: Hlbsb2C57BL/6J
Name: hepatic lipase activity in BSB 2; C57BL/6J
MGI ID: MGI:3521780
QTL: Hlbsb2  Location: unknown  Genetic Position: Chr3, cM position of peak correlated region/allele: 72.36 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94152

A population of 5 month old BSB backcross (B=C57BL/6J; S=Spret/Pt) animals (n=203) were examined for linkage to hepatic lipase activity. 148 polymorphic markers covering 90% of the genome at an average resolution of 10 cM were used in the genome scan.

Hlbsb1 (hepatic lipase activity in BSB 1) mapped to 64 cM on mouse Chromosome 7 with a peak LOD score of 4.8 near D7Mit187. Hlbsb1 accounts for approximately 10.67% of the phenotypic variance. The QTL interval of Hlbsb1 spans approximately 48 cM - 66 cM. SPRET/Pt-derived alleles confer increased hepatic lipase activity at Hlbsb1. Hlbsb1 maps near a previously identified obesity/HDL/hepatic lipase QTL named Mob1 (62 cM).

A second interacting locus was identified on mouse Chromosome 3 at 66.4 cM near D3Mit18 and is named Hlbsb2. SPRET/Pt-derived alleles confer increased hepatic lipase activity at Hlbsb2 in epistatic interactions with Hlbsb1. Animals with SPRET/Pt-derived alleles at both Hlbsb1 and Hlbsb2 exhibit enhanced hepatic lipase activity. The interaction between Hlbsb1 and Hlbsb2 explains approximately 7.03% of the phenotypic variance.

References
Original:  J:94152 Yi N, et al., Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice. J Lipid Res. 2004 Nov;45(11):2063-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory