Xirp1^tm1Jl
Targeted Allele Detail

Summary

• Symbol: Xirp1^tm1Jl
• Name: xin actin-binding repeat containing 1; targeted mutation 1, Jim Lin
• MGI ID: MGI:3521795
• Synonyms: mXinalpha
• Gene: Xirp1 Location: Chr9:119842821-119852660 bp, - strand Genetic Position: Chr9, 71.36 cM
• Alliance: Xirp1^tm1Jl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112201
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Neo-LacZ cassette was inserted into ATG initiation codon to disrupt the coding frame. The targeting vector contains a mutation to change ATG to ATC and a replacement of 203 bp downstream of ATG with the LacZ-Neo resistance cassette. Northern and Western blot analysis confirmed the absence of transcription and translation. (J:112201, J:132079)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xirp1 Mutation: 46 strains or lines available

References

• Original: J:112201 Jung-Ching Lin J, et al., Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin. J Med Sci. 2005 Oct;25(5):215-222
• All: 5 reference(s)