Igf2^tm3Wrk
Targeted Allele Detail

Summary

• Symbol: Igf2^tm3Wrk
• Name: insulin-like growth factor 2; targeted mutation 3, Wolf Reik
• MGI ID: MGI:3521799
• Synonyms: deltaDMR2, Igf2^tm3Wrk-mat, Igf2^tm3Wrk-pat
• Gene: Igf2 Location: Chr7:142204503-142220553 bp, - strand Genetic Position: Chr7, 87.99 cM
• Alliance: Igf2^tm3Wrk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94521
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 54 bp core region of DMR2 (CpG18-CpG25), in exon 6, was deleted in frame following the insertion and subsequent Cre-mediated deletion of a floxed neo. This sequence encodes the E peptide or C-terminal propeptide domain of prepro-Igf2. (J:94521)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf2 Mutation: 28 strains or lines available

Notes

ES cell line = CGR.

References

• Original: J:94521 Murrell A, et al., An intragenic methylated region in the imprinted Igf2 gene augments transcription. EMBO Rep. 2001 Dec;2(12):1101-6
• All: 3 reference(s)