Pdk4^tm1Rhar
Targeted Allele Detail

Summary

• Symbol: Pdk4^tm1Rhar
• Name: pyruvate dehydrogenase kinase, isoenzyme 4; targeted mutation 1, Robert A Harris
• MGI ID: MGI:3521806
• Synonyms: PDHK4^-
• Gene: Pdk4 Location: Chr6:5483351-5496278 bp, - strand Genetic Position: Chr6, 2.06 cM
• Alliance: Pdk4^tm1Rhar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115895
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and part of exon 2 were replaced with a PGK-neomycin resistance cassette. Western blot analysis confirmed the absence of translation product. (J:115895)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdk4 Mutation: 32 strains or lines available

References

• Original: J:115895 Jeoung NH, et al., Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation. Biochem J. 2006 Aug 1;397(3):417-25
• All: 21 reference(s)