Apc^tm2.1Cip
Targeted Allele Detail

Summary

• Symbol: Apc^tm2.1Cip
• Name: APC, WNT signaling pathway regulator; targeted mutation 2, Christine Perret
• MGI ID: MGI:3521822
• Synonyms: Apc^2lox14, Apc^fle14, Apc^lox, Apc^tm2Cpe
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm2.1Cip page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94721
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 13 and a loxP flanked PGK-Hprt cassette into intron 14. Cre mediated recombination removed a floxed HPRT cassette that was inserted into exon 14, leaving exon 14 flanked with loxP sites. (J:94721)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm2.1Cip

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:94721 Colnot S, et al., Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17216-21
• All: 36 reference(s)