Mettm3Gvw
Targeted Allele Detail
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Symbol: |
Mettm3Gvw |
Name: |
met proto-oncogene; targeted mutation 3, George Vande Woude |
MGI ID: |
MGI:3521829 |
Synonyms: |
D1226Nmu, MetD1226N |
Gene: |
Met Location: Chr6:17463799-17573979 bp, + strand Genetic Position: Chr6, 7.83 cM, cytoband A2
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Alliance: |
Mettm3Gvw page
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Germline Transmission: |
Earliest citation of germline transmission:
J:94722
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inserted expressed sequence) |
Mutation: |
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Insertion
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Mutation details: A targeting vector was designed to introduce Met exon 14-20 cDNA with a D1226N mutation downstream of exon 14, changing the GAC codon to AAC. RT-PCR and immunoblotting showed that met RNA and protein expression were equivalent to wild-type.
(J:94722)
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View phenotypes and curated references for all genotypes (concatenated display).
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List all tumor models in MMHCdb carrying
Mettm3Gvw
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Met Mutation: |
83 strains or lines available
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Original: |
J:94722 Graveel C, et al., Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17198-203 |
All: |
2 reference(s) |
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