About   Help   FAQ
Mettm3Gvw
Targeted Allele Detail
Summary
Symbol: Mettm3Gvw
Name: met proto-oncogene; targeted mutation 3, George Vande Woude
MGI ID: MGI:3521829
Synonyms: D1226Nmu, MetD1226N
Gene: Met  Location: Chr6:17463799-17573979 bp, + strand  Genetic Position: Chr6, 7.83 cM, cytoband A2
Alliance: Mettm3Gvw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94722
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to introduce Met exon 14-20 cDNA with a D1226N mutation downstream of exon 14, changing the GAC codon to AAC. RT-PCR and immunoblotting showed that met RNA and protein expression were equivalent to wild-type. (J:94722)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Mettm3Gvw
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Met Mutation:  83 strains or lines available
References
Original:  J:94722 Graveel C, et al., Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17198-203
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory