Met^tm4Gvw
Targeted Allele Detail

Summary

• Symbol: Met^tm4Gvw
• Name: met proto-oncogene; targeted mutation 4, George Vande Woude
• MGI ID: MGI:3521830
• Synonyms: M1248T/ L1193V^mu, Met^{M1284T/L1193V}, Met^mut
• Gene: Met Location: Chr6:17463799-17573979 bp, + strand Genetic Position: Chr6, 7.83 cM, cytoband A2
• Alliance: Met^tm4Gvw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94722
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: A targeting vector was designed to introduce Met exon 14-20 cDNA with M1248T and L1193V mutations downstream of exon 14, changing the ATG and CTT codons to ACG and GTT, respectively. RT-PCR and immunoblotting showed that met RNA and protein expression were equivalent to wild-type. (J:94722)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Met^tm4Gvw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Met Mutation: 83 strains or lines available

References

• Original: J:94722 Graveel C, et al., Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17198-203
• All: 4 reference(s)